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Health & Disease

Understanding the sudden rise of type 2 diabetes in children

The metabolic disorder was long known as a disease of adulthood. Now, it’s spiking in kids and teens, with worrisome consequences.

Are you a workaholic? Here’s how to spot the signs

In a major shift, psychologists now view an out-of-control compulsion to work as an addiction with its own set of risk factors and consequences

Radioactive drugs strike cancer with precision

The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects

To pee or not to pee? That is a question for the bladder — and the brain

How do we sense the need to urinate? The basic urge is surprisingly complex and can go awry as we age.

Time for half-year resolutions?

If your good intentions from a few months ago haven’t led to much, take note. A psychologist tells us what we can learn from studies on willpower.

Fit for a dog? The latest science on CBD for pets

Though studies are still mixed, and products often inconsistent, many scientists have hope that cannabidiol can help canines and other furry patients suffering from arthritis, allergies and anxiety

In defense of wild meat’s place at the table

Sustainable and safe consumption of wildlife is possible, and important for those who depend on it, says a conservation researcher

Should you take vitamin D? Here’s the science

Some people take too much, and too many get too little. Experts explain who needs D supplements, and why.

What’s next in the Ozempic era?

Diabetes, weight loss and now heart health: A new family of drugs is changing the way scientists are thinking about obesity — and more uses are on the horizon

Why isn’t dental health considered primary medical care?

Ailments of the mouth can put the body at risk for a slew of other ills. Some practitioners think dentistry should no longer be siloed.

Psychedelic drugs and the law: What’s next?

The push to legalize magic mushrooms, MDMA, LSD and other hallucinogens is likely to heighten tensions between state and federal law, drug law expert Robert Mikos says

All about cholesterol

The latest science on how blood levels of HDL, LDL and more relate to cardiovascular health

Soda taxes can’t reverse the obesity epidemic

OPINION: They might be able to help, but only if well-designed and in combination with other policies

Getting rid of bed bugs: Trickier than ever

The blood-sucking insects now show up in two varieties and are resistant to many pesticides. New eradication strategies include fungal spores and nasty human odors.

The untapped potential of stem cells in menstrual blood

Long overlooked, menstrual stem cells could have important medical applications, including diagnosing endometriosis

CRISPR gene editing: Moving closer to home

With the first medical therapy approved and systems like CRISPR-Cas showing up in complex cells, there’s a lot going on in the genome editing field. Here’s our primer.

We urgently need data for equitable personalized medicine

OPINION: A massive bias in medical studies toward men of European origin means that genetic variants in understudied populations don’t get the focus they deserve

Genes and heart disease: Finally making the link

Polygenic risk scores — a patient’s chance, based on tiny DNA variants, of developing cardiovascular disease, breast cancer and more — are coming to clinics. But there are kinks to iron out and accuracy remains an issue.

How gut bacteria connect to Parkinson’s disease

Growing evidence suggests a link between the debilitating neurological illness and the microbes that live in our intestines. The vagus nerve may be a pathway.

The growing link between microbes, mood and mental health

New research suggests that to maintain a healthy brain, we should tend our gut microbiome. The best way to do that right now is not through pills and supplements, but better food.

Scientists scrutinize happiness research

From meditation to smiling, researchers take a second look at studies claiming to reveal what makes us happy

Top science stories of 2023

Twelve standout news events and trends in a tumultuous year

Untangling the genetics that underlie our facial features

After turning up hundreds of genes with hard-to-predict effects, some scientists are now probing the grander developmental processes that shape face geometry

The remaining frontiers in fighting hepatitis C

A scientist whose work was key to identifying, studying and finding treatments for this life-threatening virus discusses the scientific journey and challenges that persist

New devices could change the way we measure blood pressure

Embedded in a cell phone or in accessories such as rings, bracelets or watches, the novel tools aim to make it easier to manage hypertension. But they must still pass several tests before hitting the clinic.

How climate change could make fungal diseases worse

Disease-causing fungi are likely to thrive in a warmer, stormier world — and more of them might be poised to make the leap to infecting people

Salt taste is surprisingly mysterious

Too much sodium is bad, but so is too little — no wonder the body has two sensing mechanisms

How optimizing indoor humidity can help stop the spread of Covid and flu

OPINION: Recent CDC guidelines for indoor air quality disregard the benefits of humidity. But research shows it can kill viruses and help thwart infections.

New noninvasive RNA tests could help identify at-risk pregnancies

The next wave of prenatal screening looks for fragments of RNA within the blood to flag risk of preeclampsia and preterm labor

Rapid experiments to improve health-care delivery

Public health experts are borrowing a technique from the tech world to make messaging more effective — so that patients are more likely to get preventive care

Preparing for future pandemics: Learning from Covid-19

VIDEO: Knowable Magazine’s interviews with experts during the pandemic revealed many missed opportunities and blunders in the US response to Covid-19, which was marked by excess American deaths and disability. The experience does offer lessons on how to better prepare for what scientists call the inevitable emergence of the next global health emergency.

Medications for opioid use disorder — MOUD — and adolescents

Treatment with drugs such as buprenorphine, methadone and naltrexone is deemed the gold standard for youth with opioid addictions. Why isn’t it used more often?

New views of a cough: From TB and chronic cough to hope for Parkinson’s

Scientists are revealing new secrets of the reflex that protects our lungs, spreads disease and irritates us all

How the placebo effect went mainstream

PODCAST: Sloppy by today’s standards, and maybe even back when it was published in 1955, Henry Beecher’s paper paved the way for sounder drug trials and pushed scientists to better understand how we process pain (Season 3, Episode 3)

Dealing with rats, and their health, in America’s ‘rattiest’ city

OPINION: A study in Chicago found that rodents surviving poisoning are more likely to carry disease. Good pest control needs to take such things into account.

The neurons that make us feel hangry

Neuroscientists think a cluster of cells in the brain that stimulate appetite could be a target for eating disorder therapies

Reading the mind with machines

Researchers are developing brain-computer interfaces that would enable communication for people with locked-in syndrome and other conditions that render them unable to speak

What if we tolerated diseases?

The immune cells that fight bacteria and viruses are well-known. But some scientists think we should devote more attention to a second prong of defense: one that allows our bodies to more harmlessly live with pathogens until they’re cleared from our systems.

Hope for haploinsufficiency diseases

Genetic conditions like Dravet syndrome, which causes severe childhood epilepsy, are hard to tackle with traditional gene therapy. New approaches in the works include using antisense therapy to boost mRNA splicing.

Amyloidosis: Beyond Alzheimer’s and Parkinson’s

Amyloid plaque can build up in body organs other than the brain. The resulting diseases — AL amyloidosis, ATTR amyloidosis and more — cause much suffering.

Saliva: The next frontier in cancer detection

Scientists are finding tumor signals in spit that could be key to developing diagnostic tests for various types of cancer

Small wonders: The antibodies from camels and sharks that could change medicine

A handful of animals make a pared-down version of these pathogen-fighting proteins of our immune system. Scientists hope to harness them as treatments for ills from cancer to Covid, for tracking cells in the body, and more.

The teen brain: Mysteries and misconceptions

VIDEO: Join a conversation about the teenage brain’s strengths and vulnerabilities, how adults can support teenagers with mental health issues, and how teens can help one another

The baby brain: Learning in leaps and bounds

VIDEO: Learn how the baby brain changes from gestation to toddlerhood, and what parents, teachers and policymakers can do to ensure kids are set up for success

The mature mind: Aging resiliently

VIDEO: Connect with brain health experts about the best ways to cultivate resilience as we age, and how to support loved ones with memory loss and dementia

Unplugging asthmatic airways

New therapies that involve the removal of mucus in the lungs might be the best strategy to beat asthma

Scientific highs and lows of cannabinoids

Hundreds of these cannabis-related chemicals now exist, both natural and synthetic, inspiring researchers in search of medical breakthroughs — and fueling a dangerous trend in recreational use

How saliva changes the flavor of food

The liquid that our mouths produce isn’t just a lubricant. It plays an active role in how we perceive taste and can influence what we choose to eat, researchers are discovering.

Covid, RSV and the flu: A case of viral interference?

The ‘tripledemic’ unfolding this winter is one of several odd trends among respiratory virus infections these last years. Viruses, it turns out, can block one another and take turns to dominate.

Could getting rid of old cells turn back the clock on aging?

Researchers are investigating medicines that selectively kill decrepit cells to promote healthy aging — but more work is needed before declaring them a fountain of youth

America is failing women’s health

OPINION: Systemic inequity means women in the US die younger and suffer more than they should. It’s time for health for all.

What’s the fittest fitness for the oldest old?

Even for 60ish youngsters, researchers reaffirm that exercise is essential. But just walking won’t cut it — break out the weights and go for strength training too.

What next-gen Covid-19 vaccines might look like

From building up defenses in the nose to slowing down a virus’s ability to make copies of itself, scientists are rolling out a raft of creative approaches to fighting infection

The vital crosstalk between breath and brain

The rhythm of respiration influences a wide range of behaviors, as well as cognition and emotion. Neuroscientists are piecing together how it all works.

How to fight Covid with light

Some wavelengths of light in a range called far-UVC kill microbes in experiments and appear to be harmless to people. Could they be used to make indoor spaces safer against the coronavirus?

Handing the surgeon’s scalpel to a robot

After decades of merely assisting doctors, are sophisticated machines ready to take charge?

She saw the obesity epidemic coming. Then an unexpected finding mired her in controversy.

Katherine Flegal was a scientist who found herself crunching numbers for the government, until one day her analyses set off a firestorm. What does she make of her decades as a woman in public health research?

The US abortion decision is already having global impacts

OPINION: The reversal of Roe v. Wade is a tragedy not just for the United States, but for women everywhere

Long Covid: A parallel pandemic

VIDEO: Tens of millions of people are living with long Covid. Yale immunologist Akiko Iwasaki explains the current state of play in the search for causes of, and treatments for, this potentially debilitating illness.

How long will it take to understand long Covid?

Covid long-haulers experience a litany of symptoms, and researchers have proposed a variety of theories to explain them. It’s a morass to figure out, but the answers are important for the multitudes still suffering from an infection that happened to them months or even years ago.

Inside the brains of aging dogs

In a citizen science project, thousands of pet dogs are helping scientists to understand what happens to memory and cognition in old age

The lasting anguish of moral injury

Psychologists are finding that moral code violations can leave an enduring mark — and may require new types of therapy

Making microbots smart

What would it take to create a truly intelligent microbot, one that can operate independently? A roboticist describes the fascinating minutiae and the medical jobs these tiny machines could do for us.

This myth about guns is killing us

OPINION: The idea that gun violence prevention research is at odds with gun rights is just not true

Sex, immunity and the brain

Differences between the immune systems of males and females — in particular, ones involving cells called microglia — might help explain why the risk for conditions such as autism and Alzheimer’s varies between the sexes

Covid and the brain: A neurological health crisis

VIDEO: Even a mild SARS-CoV-2 infection can cause inflammation that disrupts neural communication, says Stanford neurologist Michelle Monje. Her concern is that Covid-19 may leave millions dealing with cognitive problems, from a loss of mental sharpness to lapses in memory, that prevent them from returning to their previous level of function.

Does online opioid treatment work?

The Covid-19 pandemic brought a sudden shift to virtual health care. That has increased access — and possibly outcomes, too — for patients with opioid use disorder.

How antidepressants changed ideas about depression

PODCAST: Serendipitous discoveries led to drugs like Prozac and to new insights into the physical basis of this debilitating disorder. But scientists continue to search for deeper understandings and therapies that will bring relief to those who still struggle. (Season 2, Episode 6)

Vaccinating the world against Covid-19

Lower-income countries haven’t gotten an equal share of lifesaving coronavirus vaccines. Older, more familiar vaccine technologies may hold the key to more equitable use, says Maria Elena Bottazzi.

The first malaria vaccine is a leap forward, but we can’t stop now

OPINION: Next-generation vaccines, and a lot more money, are needed now to crack the stalemate in the fight against malaria

Covid-19: Origins of an outbreak

VIDEO: Where do new diseases come from? As people increasingly push into remote areas, the risk of encountering new pathogens increases, says wildlife epidemiologist Jonna Mazet.

Bear hibernation: More than a winter’s nap

The creatures’ annual protracted snoozes have much to tell us about the biology of mammals, ourselves included. Now scientists are watching to see how bears will tweak their habits as the climate warms.

The pain of prolonged grief disorder

Psychologists are beginning to understand that for some people, intense and sustained feelings of loss are symptoms of a serious condition — one that can last for years and erode wellbeing

A path to Covid-19 vaccine equity

VIDEO: When can the people who still need a Covid-19 vaccine expect to get one? Delve into the supply, distribution and political issues delaying global access to a lifesaving, economy-rescuing marvel.

Pandemic psychology: Nothing new under the Sun

OPINION: Our behavior during Covid-19 echoes that of individuals, societies and governments during past plagues. We can and should do better.

The science of placebos is fueling quackery

OPINION: The placebo effect is real. So are the ethical conundrums posed by those who would exploit the latest research advances for profit.

Fun facts about bones: More than just scaffolding

A new vision of the skeleton as a dynamic organ that sends and receives messages suggests potential therapies for osteoporosis and other problems

Lyme and other tick-borne diseases are on the rise. But why?

The complex interplay of ticks, their habitats and hosts — along with changes in land use and climate — may be enabling the spread of the pathogens they carry

When depression sneaks up on menopause

Fluctuating levels of estrogen during a period known as perimenopause can wreak havoc on the mental health of women in midlife. Diagnosis and treatment have been elusive despite symptoms as serious as suicidal thoughts.

Exercise boosts the brain — and mental health

Working out buffs up the body — and perhaps the mind, too. New research is revealing how physical activity can reduce and even ward off depression, anxiety and other psychological ailments.

New antifungal medications are sorely needed

Better treatment for Candida auris, Aspergillus and other dangerous fungal pathogens is slow to come, even as rates of drug resistance rise. New therapies are in the pipeline, and hospital practices can help.

How zinc helps you fight off infections

Our bodies require the vital mineral for the healthy functioning of the immune system 

The vicious cycle of food and sleep

OPINION: More than a third of Americans don’t log enough hours in bed, provoking serious impacts on their health. Diet is an important and under-recognized reason.

Searching for a better treatment for eating disorders

Cognitive behavioral therapy is proving to work well, but only for some patients. Scientists are seeking new innovations to help people grappling with the pervasive and often-hidden problems of anorexia, bulimia and binge eating.

How racism in early life can affect long-term health

OPINION: Excessive adversity activates biological reactions that can lead to lifelong problems in physical and mental wellbeing

Question the ‘lab leak’ theory. But don’t call it a conspiracy.

OPINION: If there’s one thing the pandemic has taught us, labels get in the way of facts and make the truth that much harder to find.

Why sleep matters for personal and public health

VIDEO: Disrupted sleep ups the risks for heart disease, cancer and depression. How? And what can be done about the inequities that leave communities of color and poor people at greater risk? 

What does it mean to have prediabetes?

It’s complicated: Prediabetes has multiple definitions and there may be different subtypes. But for many people who develop it, changes in lifestyle drastically lower the risk of progressing to diabetes.

Let’s change how we pay for hospitals

OPINION: Many health facilities were already in fiscal straits before Covid-19 — except in Maryland. The state’s innovative and sound approach could be the answer to rescuing systems nationwide.

Viral variants: From Covid to the flu

VIDEO: Some variants of SARS-CoV-2, such as Delta, will drive new waves of COVID-19 infections. What can previous studies of the flu, HIV and SARS tell us about the course that this pandemic may take?

Why Covid-19 testing went so wrong in the US, and what to do now

VIDEO: Delays, errors and a fragmented response initially kept public health officials in the dark about the spread of SARS-CoV-2. More tests and easy access could still play a critical role in slowing the virus.

Why we are developing a patent-free Covid antiviral therapy

OPINION: During global health crises such as pandemics, drug discovery should be publicly funded and open, with no research secrets locked away

Covid’s main lesson? For this journalist, it’s unpredictability

VIDEO: New York Times science reporter Apoorva Mandavilli chronicles the rise of the delta variant, the latest of many twists in the pandemic that she’s covered since it began. Delta has left parents in an especially tough spot, with schools opening but young children still vulnerable.

To understand airborne transmission of disease, follow the flow

Viruses and bacteria travel in fluids, such as the air we breathe. Studying exhalations, toilet flushes and rain drops, with math and modeling, can sharpen the big-picture view of how to prevent infections.

Why don’t kids tend to get as sick from Covid-19?

Some children have been hospitalized and some have died, but at a tiny fraction of the adult rate. As children head back to school, scientists are hoping that research will provide answers.

Tackling the growing problem of overmedication

Polypharmacy — taking five or more meds at a time — leads to side effects, unnecessary hospitalizations and premature deaths. Researchers and pharmacists are seeking solutions to this serious public health problem that disproportionately affects older adults.

Studying poverty through a child’s eyes

Research on early-life adversity should pay more attention to the perspective of children themselves

Building an immune system for the planet could prevent the next pandemic

OPINION: We need a global information network that spans borders so we can spot — and stop — new pathogens before they threaten world health

What will history say about Covid? Museums scurry to collect — and prepare to remember.

A worn pair of nurse’s shoes. That coronavirus model Anthony Fauci used in public briefings. Oral histories, iconic photos and social media posts. All of us are curators now, and what we preserve — as well as what we don’t — will write the pandemic story.

Foods of abuse? Nutritionists consider food addiction

Cookies, chips, hot dogs and other ultraprocessed fare raise risk of runaway eating

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